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KMID : 1137820180390030140
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의공학회지
2018 Volume.39 No. 3 p.140 ~ p.145
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The Biostability and Cancer Effect of PLGA Nanoparticles with Different Charges
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Kim In-Woo
Park Seung-Bin
Ji Yu-Hyun
Park Sang-Hyo
Key Jae-Hong
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Abstract
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Cancer is a major burden of human disease worldwide. Current chemotherapy has severe side effects because the drugs affect whole body nonspecifically. In addition, the drugs to reach cancer cells are very limited. Over the last two decades, Drug Delivery System (DDS) using nanoparticles has suggested promising results to improve current limitations. In this study, we prepared PLGA nanoparticles with different charge properties and observed their stability and internalization effect to cancer cells. Results using Dynamic Light Scattering (DLS) and Fourier Transform Infrared Spectroscopy (FTIR) confirmed the size and chemical composition of the nanoparticles. The stability of the nanoparticles in pH buffers were variable depending on charge properties. The nanoparticles showed different cytotoxicity and internalization effects to MCF-7 human breast cancer cells. In conclusion, we demonstrated the importance of delicately engineered nanoparticles for better DDS in cancer.
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KEYWORD
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Cancer therapy, Drug delivery, Nanoparticle, Zeta potential
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